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Renat Kornilov
Renat Kornilov

Milk Dee Deep Canic - Time To Time Extra Quality



Recently, several cell types, which bridge between innate and adaptive immunity, have been shown to play key roles in skin wound healing. Upon injury, plasmacytoid dendritic cells (pDCs) infiltrate in skin wounds at the same time as neutrophils [25]. pDCs sense host-derived nucleic acids released in the wound and transiently produce type I interferons (IFN-α/β) via TLR7- and TLR9-dependent mechanisms, which process is critical for the induction of early inflammatory responses and re-epithelialization of injured skin [25]. Langerhans cells (LCs) are a specialized subset of epidermal dendritic cells, which serve as first-line defender, contributing to epidermal immune surveillance. Increased epidermal LCs has been observed at wound edges during early phases of normal wound healing, although the exact protective mechanism of these cells is unknown [26, 27]. Moreover, higher number of LCs in the epidermis of diabetic foot ulcers has been reported to correlate with healing outcome [27]. Different from the well-defined αβT cell, γδT cell is a subset of T cells expressing T cell antigen recognition receptor (TCR) composed of γ and δ subunits. The subpopulation of γδT cells in the epidermis is known as dendritic epidermal T cells (DETC) [12]. In skin wounds, γδT cells can recognize and eliminate damaged keratinocyte, release growth factors, e.g., fibroblast growth factor (FGF)-7, keratinocyte growth factor (KGF)-1 and insulin-like growth factor (IGF)-1, which stimulate proliferation of neighbouring healthy keratinocytes (reviewed in [12]). In human acute wounds both αβ- and γδ- skin-resident T cells have been shown to actively produce IGF-1, whereas skin-resident T cells isolated from chronic wounds do not express IGF-1 and exhibit an unresponsive state [28]. Also, a subpopulation of γδT cells produces IFN-γ, enhancing the antimicrobial, antitumor and other functions of NK and αβT cells. Another subpopulation of γδT cells produce IL-17 and induce expression of multiple host-defense molecules in epidermal keratinocytes, promoting wound healing [29].




Milk Dee Deep Canic - Time To Time



In Greek Mythology, Canis Major represented the dog Laelaps, a gift from Zeus to Europa; or sometimes the hound of Procris, Diana's nymph; or the one given by Aurora to Cephalus, so famed for its speed that Zeus elevated it to the sky.[5] It was also considered to represent one of Orion's hunting dogs,[6] pursuing Lepus the Hare or helping Orion fight Taurus the Bull; and is referred to in this way by Aratos, Homer and Hesiod. The ancient Greeks refer only to one dog, but by Roman times, Canis Minor appears as Orion's second dog. Alternative names include Canis Sequens and Canis Alter.[5] Canis Syrius was the name used in the 1521 Alfonsine tables.[5]


Both the Māori people and the people of the Tuamotus recognized the figure of Canis Major as a distinct entity, though it was sometimes absorbed into other constellations. Te Huinga-o-Rehua, also called Te Putahi-nui-o-Rehua and Te Kahui-Takurua, ("The Assembly of Rehua" or "The Assembly of Sirius") was a Māori constellation that included both Canis Minor and Canis Major, along with some surrounding stars.[14][15] Related was Taumata-o-Rehua, also called Pukawanui, the Mirror of Rehua, formed from an undefined group of stars in Canis Major.[16][17] They called Sirius Rehua and Takarua, corresponding to two of the names for the constellation, though Rehua was a name applied to other stars in various Māori groups and other Polynesian cosmologies.[18][19] The Tuamotu people called Canis Major Muihanga-hetika-o-Takurua, "the abiding assemblage of Takarua".[20]


Flanking Sirius are Beta and Gamma Canis Majoris. Also called Mirzam or Murzim, Beta is a blue-white Beta Cephei variable star of magnitude 2.0, which varies by a few hundredths of a magnitude over a period of six hours.[34] Mirzam is 500 light-years from Earth, and its traditional name means "the announcer", referring to its position as the "announcer" of Sirius, as it rises a few minutes before Sirius does.[6] Gamma, also known as Muliphein, is a fainter star of magnitude 4.12, in reality a blue-white bright giant of spectral type B8IIe located 441 light-years from earth.[35] Iota Canis Majoris, lying between Sirius and Gamma, is another star that has been classified as a Beta Cephei variable, varying from magnitude 4.36 to 4.40 over a period of 1.92 hours.[36] It is a remote blue-white supergiant star of spectral type B3Ib, around 46,000 times as luminous as the sun and, at 2500 light-years distant, 300 times further away than Sirius.[37]


Epsilon, Omicron2, Delta, and Eta Canis Majoris were called Al Adzari "the virgins" in medieval Arabic tradition.[38] Marking the dog's right thigh on Bayer's atlas is Epsilon Canis Majoris,[33] also known as Adhara. At magnitude 1.5, it is the second-brightest star in Canis Major and the 23rd-brightest star in the sky. It is a blue-white supergiant of spectral type B2Iab, around 404 light-years from Earth.[39] This star is one of the brightest known extreme ultraviolet sources in the sky.[40] It is a binary star; the secondary is of magnitude 7.4. Its traditional name means "the virgins", having been transferred from the group of stars to Epsilon alone.[41] Nearby is Delta Canis Majoris, also called Wezen. It is a yellow-white supergiant of spectral type F8Iab and magnitude 1.84, around 1605 light-years from Earth.[42] With a traditional name meaning "the weight", Wezen is 17 times as massive and 50,000 times as luminous as the Sun. If located in the centre of the Solar System, it would extend out to Earth as its diameter is 200 times that of the Sun. Only around 10 million years old, Wezen has stopped fusing hydrogen in its core. Its outer envelope is beginning to expand and cool, and in the next 100,000 years it will become a red supergiant as its core fuses heavier and heavier elements. Once it has a core of iron, it will collapse and explode as a supernova.[43] Nestled between Adhara and Wezen lies Sigma Canis Majoris, known as Unurgunite to the Boorong and Wotjobaluk people,[23] a red supergiant of spectral type K7Ib that varies irregularly between magnitudes 3.43 and 3.51.[44]


Also called Aludra, Eta Canis Majoris is a blue-white supergiant of spectral type B5Ia with a luminosity 176,000 times and diameter around 80 times that of the Sun.[45] Classified as an Alpha Cygni type variable star, Aludra varies in brightness from magnitude 2.38 to 2.48 over a period of 4.7 days.[46] It is located 1120 light-years away. To the west of Adhara lies 3.0-magnitude Zeta Canis Majoris or Furud, around 362 light-years distant from Earth.[47] It is a spectroscopic binary, whose components orbit each other every 1.85 years, the combined spectrum indicating a main star of spectral type B2.5V.[48]


Between these stars and Sirius lie Omicron1, Omicron2, and Pi Canis Majoris. Omicron2 is a massive supergiant star about 21 times as massive as the Sun.[49] Only 7 million years old,[49] it has exhausted the supply of hydrogen at its core and is now processing helium.[50] It is an Alpha Cygni variable that undergoes periodic non-radial pulsations, which cause its brightness to cycle from magnitude 2.93 to 3.08 over a 24.44-day interval.[51] Omicron1 is an orange K-type supergiant of spectral type K2.5Iab that is an irregular variable star, varying between apparent magnitudes 3.78 and 3.99.[52] Around 18 times as massive as the Sun, it shines with 65,000 times its luminosity.[53]


North of Sirius lie Theta and Mu Canis Majoris, Theta being the most northerly star with a Bayer designation in the constellation.[54] Around 8 billion years old, it is an orange giant of spectral type K4III that is around as massive as the Sun but has expanded to 30 times the Sun's diameter.[55] Mu is a multiple star system located around 1244 light-years distant,[56] its components discernible in a small telescope as a 5.3-magnitude yellow-hued and 7.1-magnitude bluish star.[57] The brighter star is a giant of spectral type K2III,[56] while the companion is a main sequence star of spectral type B9.5V.[58] Nu1 Canis Majoris is a yellow-hued giant star of magnitude 5.7, 278 light-years away; it is at the threshold of naked-eye visibility. It has a companion of magnitude 8.1.[6]


At the southern limits of the constellation lie Kappa and Lambda Canis Majoris. Although of similar spectra and nearby each other as viewed from Earth, they are unrelated.[26] Kappa is a Gamma Cassiopeiae variable of spectral type B2Vne,[59] which brightened by 50% between 1963 and 1978, from magnitude 3.96 or so to 3.52.[60] It is around 659 light-years distant.[61] Lambda is a blue-white B-type main sequence dwarf with an apparent magnitude of 4.48 located around 423 light-years from Earth.[62] It is 3.7 times as wide as and 5.5 times as massive as the Sun, and shines with 940 times its luminosity.[54] 041b061a72


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